From Computational Genomics
By the introduction of high-throughput technologies, more and more genome sequencing projects successfully accomplished, leading to further demands to computerized methods targeting precise prediction of genes and their functionality. During the past decades, a considerable part of the Bioinformaticians' efforts has been devoted to genome sequencing and annotation projects. On the other hand, gene finding methods have been constantly subject to new improvements due to the introduction and employment of newer and more efficient statistical, mathematical and heuristic approaches.
Prof. Mark Borodovsky is a Regents' Professor at the departments of of Biomedical Engineering and Computational Science and Engineering and director of Center for Bioinformatics and Computational Genomics at Georgia Institute of Technology. In 1990, he started developing a new line of Gene Finding algorithms, by introducing the idea of considering genes as signals coming from Markov Models, for the first time. The initial product of his idea was called GeneMark which was a leading technique in its kind. GeneMark soon emerged as a totally successful approach for revealing the genes characteristics inside different genomes. Since its introduction, GeneMark has been constantly improved and extended leading to other significant variations such as GeneMarkS, GeneMark.hmm, GeneMark Genesis, etc. Prof. Borodovsky is also the author for the book "Problems and solutions in biological sequence analysis" and has published dozens of highly valued research articles and book chapters.